Yohimbine HCL USP |
General Information |
| Yohimbine HCL USP is an extract form the bark of Pausinystalia yohimbe tree(formerly Corynanthe yohimbe ). It is grown in South Africa and known worldwide as an excellent aphrodisiac. Pausinystalia yohimbe tree bark contains 25 to 30 other yohimbane alkaloids found in Yohimbe.Yohimbine are also known under the synonyms yohimbinum,quebrachin, aphrodin, corynine yohimbin, johimbine, , corynine, yohimvetol etc. |
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| Application: Alpha-Adrenergic Blocker Mydriatic |
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Chemical Name :17 ---alpha-hydroxy –20-alpha-yohimban-16-beta-carboxylic acid, methyl ester, hydrochloride.
Product Description & identification
| Details |
| CAS NO. |
65-19-0 |
| FORMULA |
C21H26O3N2 * HCL |
| MOLECULAR WEIGHT |
390.91 |
| SYNONYMS |
QUEBRACHINE, APHRODINE |
| PACKING |
500 Gms 1, 2 and 5 Kg |
| MELTING POINT |
285°C to 288°C |
Product Specification
| Parameters |
Requirement / Limit |
Results |
| Appearance |
White to off white powder
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Off White Powder
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Loss on drying (LOD)
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NMT 1.0 %
|
0.42 %
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Specific Rotation
|
+1000 to +1050 |
+103.140
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Assay by HPLC
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NLT 98.0 % w/w
NMT 102.0 % w/w
( On dry basis)
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99.57 % w/w
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TLC test
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Should Comply
|
Complies |
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Related Substance
i) Single Highest Impurity
ii) Total Impurities
|
NMT 1.0 %
NMT 2.0 %
|
0.22 %
0.26 %
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Other test (IH)
i) UV/VIS test
(0.1 N HCL in Methanol)
ii) ‘D’ test as per USP
iii) F.T.I.R Test
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Should Comply
Should Comply
Should Comply
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Complies
Complies
Complies
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Residual Solvents
(Volatiles Impurities)
i) Methanol
ii) Chloroform
iii) Toluene
|
3000 ppm
60 ppm
890 ppm
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297 ppm
Not detected
Not detected
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This product confirm to specifications. |
